All voltage rails are 5V, the input voltages on the data lines reach 5V and 0V checked with scope, so no problem there.
P24 Vdd IS connected to 5V, typo above.
The specific part i'm using is TI -
CD74HC4067M96

Attached schematic to help.
The problem seems related to D1 input on 4067 only. All other inputs work (when D1 = 0) so I can access 50% of the channels.
If I try to tie D1 to 5V I don't get any channels switching through.
This is an interesting one. BTW I have tried two 4067 chips, but they are from the same batch though...
Going to order some from different manufactures to try.
But still any further input or suggestions will be much appreciated.
it is almost like D1 and ENABLE is back to front ??? if i did it i would understand,, but the wiring has been checked MANY times...